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¡¾Major Papers of the Laboratory¡¿
?Miyaji T, Kasuya R, Monden M, Tamura Y, Shimozuru M, Tsubota T, Tsukamoto D, Li G, Kawano S, Watanabe Y, Yamaguchi Y, Watanabe M, and Miyazaki M*. Cold-induced suppression of myogenesis in skeletal muscle stem cells contributes to delayed muscle regeneration during hibernation. The FASEB Journal, 2025 December 15;Volume 39, Issue 23, e71297.
?Miyazaki M*, Shimozuru M, Kitaoka Y, Takahashi K and Tsubota T. Regulation of protein and oxidative energy metabolism are down-regulated in the skeletal muscles of Asiatic black bears during hibernation. Scientific Reports. 2022;12: 19723.
?Moriya N and Miyazaki M*, Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation, American Journal of Physiology -Regulatory, Integrative and Comparative Physiology-, 2018;314(5):R741-R751.
?McCarthy JJ, Mula J, Miyazaki M, Erfani R, Garrison K, Farooqui AB, Srikuea R, Lawson BA, Grimes B, Keller C, Van Zant G, Campbell KS, Esser KA, Dupont-Versteegden EE and Peterson CA, Effective fiber hypertrophy in satellite cell-depleted skeletal muscle, Development, 2011 Sep;138(17):3657-66.

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Integrative Physiology provides foundational medical education in physiology and exercise physiology for students in the health sciences. 
In physiology courses, students learn the fundamental mechanisms underlying human body functions, including neural, muscular, cardiovascular, respiratory, and metabolic systems, with emphasis on the maintenance of physiological homeostasis.
In exercise physiology, we focus on physiological responses to exercise and inactivity, muscle function, and energy metabolism. Through laboratory-based physiology training, students acquire practical skills for evaluating physiological functions using biological measurements and exercise-loading experiments, while also developing scientific thinking and data analysis abilities. 
We provide physiology education that serves as a foundation for clinical practice and research to students in occupational therapy, physical therapy, nursing, and related health science programs.

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Skeletal muscle is a highly plastic tissue that dynamically adapts to exercise, inactivity, nutrition, aging, and disease. Our laboratory investigates the mechanisms underlying skeletal muscle homeostasis and adaptive responses through integrative approaches spanning molecular, cellular, and whole-body physiology. 
Our major research topics include the molecular mechanisms of muscle atrophy and hypertrophy, skeletal muscle adaptation to exercise and metabolic stress, muscle dysfunction associated with aging and cancer cachexia, regulation of skeletal muscle satellite cells, circadian regulation of skeletal muscle metabolism, and mechanisms maintaining muscle homeostasis during hibernation and artificial hibernation. A particular focus of our laboratory is understanding why hibernating animals remarkably preserve skeletal muscle mass and function despite prolonged inactivity. Using both natural and artificial hibernation models, we aim to elucidate the molecular basis of ¡°atrophy-resistant muscle.¡± 
To address these questions, we combine molecular biology, biochemistry, cell biology, animal physiology, and multi-omics approaches to investigate skeletal muscle adaptation from multiple perspectives. Ultimately, our goal is to translate these findings into novel preventive and therapeutic strategies against sarcopenia, disuse atrophy, and cancer cachexia.