ÑÇÉ«ÊÓƵ

Japanese

A leading bioethicist at ÑÇÉ«ÊÓƵ is calling for an anticipatory, rather than reactive, approach to ethics after a Japanese government panel in August backed a report that brings the country a step closer to becoming the first in the world to allow research on human embryos created from stem cell¨Cderived sperm and eggs.

In a correspondence article titled "" published in the journal Nature (Vol. 646), ÑÇÉ«ÊÓƵ Professor (Special Recognition) Tsutomu Sawai cautions that science is advancing faster than society¡¯s ability to debate its implications. He urges ethicists to ¡°engage in forward-looking debate to prevent researchers from rushing into controversial experiments.¡±

He points to the 2018 gene-edited babies scandal as a cautionary example of what can happen when technology outpaces ethical review. In that case, a Chinese scientist announced the birth of the world¡¯s first gene-edited babies, the result of experiments using the CRISPR-Cas9 tool to make embryos resistant to HIV. The researcher drew global outrage for the risky experiments on human embryos that flouted established ethical norms and oversight expectations.

¡°An anticipatory approach is needed: to assess social effects early, define boundaries in plain language and design governance that can evolve as evidence develops. It should include safeguards against misuse, and clear red lines for any credible signs of sentience,¡± Sawai said.

¡°The goal is not to restrain science but to guide it with foresight.¡±

According to the Japan panel¡¯s report, culturing embryos in the laboratory will be limited to 14 days, and implantation into a human or animal uterus will be prohibited. So far, it is not yet feasible to create from human pluripotent stem cells, such as iPS cells. However, it is expected to become possible in about , an advancement that could accelerate research on treatments for infertility and genetic disorders. 
 

Journal: Nature
Title: Ethics must keep pace with embryo research
Authors: Tsutomu Sawai
DOI: